SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant |X| Filed by a Party other than the Registrant |_| Check
the appropriate box:
|_|Preliminary Proxy Statement
|_| Confidential, for Use of the Commission Only (as permitted by
     Rule 14a-6(e)(2))
|X| Definitive Proxy Statement
|_| Definitive Additional Materials
|_| Soliciting Material Pursuant to Rule 14a-12

                           PATIENT INFOSYSTEMS, INC.
                ------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box): |X| No fee required.
|_| Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11. (1)
Title of each class of securities to which transaction applies:_________________

(2) Aggregate number of securities to which transaction applies:________________

(3)     Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):______________
(4)     Proposed maximum aggregate value of transaction:________________________

(5) Total fee paid:_____________________________________________________________

     |_|  Fee paid previously with preliminary materials:

     |_|  Check box if any part of the fee is offset as provided by Exchange Act
          Rule  0-11(a)(2)  and identify the filing for which the offsetting fee
          was paid  previously.  Identify  the previous  filing by  registration
          statement number, or the form or schedule and the date of its filing.

     (1)  Amount Previously Paid:_______________________________________________

     (2)  Form, Schedule or Registration Statement No.:_________________________

     (3)  Filing Party:_________________________________________________________

     (4)  Date Filed:___________________________________________________________

================================================================================


                            Patient Infosystems, Inc.
                                46 Prince Street
                            Rochester, New York 14607

December 2, 2004


Dear Fellow Stockholder:

     You are cordially  invited to attend the Patient  Infosystems,  Inc. Annual
Meeting of  Stockholders  to be held at 10:00 a.m.  Eastern  Standard  Time,  on
December 23, 2004, at the offices of Patient  Infosystems,  Inc., 46 Prince St.,
Rochester, NY 14607.

     The matters proposed for  consideration at the meeting are (i) the election
of six  directors,  (ii) the approval of an amendment to our Second  Amended and
Restated Stock Option Plan (a) to expand the class of eligible  participants  of
such plan to include  nominees to the Board of Directors and consultants and (b)
to  increase  from  36,000 to  50,000  the  number  of  shares  of common  stock
underlying the one-time grant of a  Non-Qualified  Option to which  non-employee
directors or  non-employee  nominees of the Board of Directors  may be entitled,
(iii) the  ratification  of the appointment of McGladrey & Pullen LLP as the our
auditors, and (iv) the transaction of such other business as may come before the
meeting or any adjournment thereof. The accompanying Notice of Annual Meeting of
Stockholders  and Proxy Statement  discuss these matters in further  detail.  We
urge you to review this information carefully.

     You will  have an  opportunity  at the  meeting  to  discuss  each  item of
business  described in the Notice of Annual  Meeting of  Stockholders  and Proxy
Statement and to ask questions about us and our operations.

     It is  important  that your shares be  represented  and voted at the Annual
Meeting.  Whether or not you plan to attend, please sign and promptly return the
enclosed proxy card,  using the envelope  provided.  If you do attend the Annual
Meeting, you may withdraw your proxy and vote your shares in person.


Sincerely,

/s/Roger L. Chaufournier

Roger L. Chaufournier
Chairman and Chief Executive Officer






                            Patient Infosystems, Inc.
                                46 Prince Street
                            Rochester, New York 14607

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TO BE HELD MEETING DATE

     Notice is hereby given that the Annual Meeting of Stockholders (the "Annual
Meeting") of Patient Infosystems,  Inc. (the "Company") will be held on December
23,  2004 at  10:00  a.m.  Eastern  Standard  Time  at the  offices  of  Patient
Infosystems,  Inc.,  46  Prince  St.,  Rochester,  NY 14607 for the  purpose  of
considering and voting upon the following matters:

     1.   The  election of six  directors to hold office for the terms set forth
          in the accompanying proxy statement;

     2.   The  approval of an  amendment  to the  Company's  Second  Amended and
          Restated  Stock  Option  Plan to (a)  expand  the  class  of  eligible
          participants  of  such  plan  to  include  nominees  to the  Board  of
          Directors and consultants,  and (b) increase from 36,000 to 50,000 the
          number of shares of common stock  underlying  the one-time  grant of a
          Non-Qualified  Option to which non-employee  directors or non-employee
          nominees of the Board of Directors may be entitled;

     3.   The  ratification  of the appointment of McGladrey & Pullen LLP as the
          Company's independent auditors for the fiscal year ending December 31,
          2004; and

     4.   Such other  business as may properly come before the Annual Meeting or
          at any adjournment  thereof,  including  whether or not to adjourn the
          Annual Meeting.

     Stockholders  of record at the close of business  on November  30, 2004 are
entitled  to notice  of,  and to vote at,  the  Annual  Meeting.  If you plan on
attending the Annual Meeting,  please mark the appropriate box on the proxy card
so we can reserve enough space to accommodate all attendees.

     All  stockholders  are  cordially  invited to attend  the  Annual  Meeting.
Whether or not you contemplate attending the Annual Meeting,  please execute the
enclosed  proxy and return it to the  Company.  You may revoke your proxy at any
time  prior  to the  exercise  of the  proxy by  delivering  written  notice  of
revocation  to the  Company.  A return  envelope,  which  requires no postage if
mailed in the United States, is enclosed for your convenience.

     You are  respectfully  urged to read the Proxy Statement  contained in this
booklet  for  further  information   concerning  the  individuals  nominated  as
directors,  the amendment to the  Company's  Second  Amended and Restated  Stock
Option Plan, the  ratification of McGladrey & Pullen LLP as auditors and the use
of the proxy.

     A copy of the Company's  Annual Report to Stockholders  for the fiscal year
ended  December 31, 2003 and  Quarterly  Report for the  quarterly  period ended
September 30, 2004, accompanies this Proxy Statement.

By Order of the Board of Directors,

/s/Roger L. Chaufournier

Roger L. Chaufournier
Chairman and Chief Executive Officer

December 2, 2004

                    IMPORTANT - PLEASE MAIL YOUR SIGNED PROXY
                        PROMPTLY IN THE ENCLOSED ENVELOPE



                            Patient Infosystems, Inc.
                                46 Prince Street
                            Rochester, New York 14607
                            -------------------------

                                 PROXY STATEMENT
                         ANNUAL MEETING OF STOCKHOLDERS
                          TO BE HELD DECEMBER 23, 2004
                          ----------------------------

     We are providing these proxy materials in connection with the  solicitation
by the Board of  Directors  of  Patient  Infosystems,  Inc.  (the  "Company"  or
"Patient Infosystems") of proxies to be voted at the Company's Annual Meeting of
Stockholders (the "Annual Meeting"), to be held on December 23, 2004, and at any
postponement or adjournment of the Annual Meeting.

     You are cordially invited to attend the Annual Meeting, which will begin at
10:00 a.m. local time. The Annual Meeting will be held at the offices of Patient
Infosystems, Inc., 46 Prince St., Rochester, NY 14607.

     The Company is first mailing this proxy statement and proxy card (including
voting  instructions)  on or about December 2, 2004, to persons who were Patient
Infosystems  stockholders  at the close of business on November  30,  2004,  the
record  date for the Annual  Meeting.  The  principal  executive  offices of the
Company are located at the address indicated above.

     The  enclosed  proxy is  solicited by the Board of Directors of the Company
and will be voted at the Annual  Meeting and any  adjournments  thereof.  Shares
represented by a properly  executed proxy in the accompanying form will be voted
at the Annual  Meeting in  accordance  with any  instructions  specified  by the
stockholder.  If no instructions  are given,  the  stockholder's  shares will be
voted in accordance with the  recommendations of the Board of Directors FOR each
of the proposals  presented in this proxy statement.  Those  recommendations are
described later in this proxy statement.

     The proxy may be revoked at any time before it is exercised by delivering a
written notice of revocation to the Assistant  Secretary of the Company.  If you
attend the Annual Meeting in person,  you may revoke your proxy by either giving
notice of revocation to the  Inspectors  of Election at the Annual  Meeting,  by
delivering a duly executed proxy bearing a later date or by voting at the Annual
Meeting in person.

     The only items of business  that the Board of Directors  intends to present
or knows will be presented at the Annual Meeting are the items discussed in this
proxy  statement.  The proxy confers  discretionary  authority  upon the persons
named therein, or their substitutes, to vote on any other items of business that
may properly come before the meeting.

     Only  stockholders of record at the close of business on Tuesday,  November
30,  2004,  the record date for the Annual  Meeting  (the  "Record  Date"),  are
entitled to notice of and to vote at the Annual Meeting.  As of the Record Date,
the  Company  had  9,638,150  shares of Common  Stock,  par value $.01 per share
("Common Stock"), issued and outstanding,  75,000 shares of Series C Convertible
Preferred Stock with voting  privileges  equal to 800,000 shares of Common Stock
outstanding,  and 840,118  shares of Series D Convertible  Preferred  Stock with
voting  privileges equal to 9,151,180 shares of Common Stock  outstanding.  Each
share of Common Stock is entitled to one vote on each matter submitted to a vote
at the Annual Meeting. Stockholders have no cumulative voting rights.

                                       1


                                VOTING PROCEDURES

     The  election  of the  directors  will  be by  the  affirmative  vote  of a
plurality  of the shares of Common  Stock  present in person or  represented  by
proxy at the Annual  Meeting,  provided a quorum  exists.  The  ratification  of
McGladrey & Pullen LLP as auditors,  the approval of the  amendment to the Stock
Option Plan and all other matters at the meeting will be by the affirmative vote
of a majority of the shares of Common Stock present in person or  represented by
proxy at the Annual Meeting,  provided a quorum exists.  A quorum is established
if, at least a  majority  of the  outstanding  shares of Common  Stock as of the
Record Date are present in person or represented by proxy at the Annual Meeting.

     You may own Common Stock  either (1)  directly in your name,  in which case
you are the record holder of such shares,  or (2)  indirectly  through a broker,
bank or other nominee,  in which case such nominee is the record holder. If your
shares of Common  Stock are  registered  directly  in your name,  the Company is
sending  these proxy  materials  directly  to you. If the record  holder of your
shares of Common Stock is a nominee,  you will receive proxy materials from such
record holder.

     Votes will be counted and  certified by one or more  Inspectors of Election
who are expected to be employees of the Company or Continental  Stock Transfer &
Trust Company,  the Company's  stock transfer agent. In accordance with Delaware
law,  abstentions and "broker  non-votes" (i.e. proxies from brokers or nominees
indicating that such persons have not received  instructions from the beneficial
owner or other  persons  entitled to vote shares as to a matter with  respect to
which the brokers or nominees do not have  discretionary  power to vote) will be
treated as present for purposes of  determining  the  presence of a quorum.  For
purposes  of  determining  approval  of  a  matter  presented  at  the  meeting,
abstentions  will be deemed  present and  entitled to vote and will,  therefore,
have the same  legal  effect  as a vote  "against"  a  matter  presented  at the
meeting.  Broker  non-votes  will be deemed not  entitled to vote on the subject
matter as to which the non-vote is indicated and will, therefore, generally have
no legal effect on the vote on that particular matter.

     Each  stockholder may revoke a previously  granted proxy at any time before
it is exercised by filing with the Company  either a notice of  revocation  or a
duly executed  proxy bearing a later date.  The powers of the proxy holders will
be suspended if the person executing the proxy attends the meeting in person and
so  requests.  Attendance  at  the  meeting  will  not,  in  itself,  constitute
revocation of a previously granted proxy.


                                       2


                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

     At this year's Annual Meeting, six directors will be elected to hold office
for a term expiring at the next Annual Meeting. Each director will be elected to
serve until a successor is elected and qualified or until the director's earlier
resignation  or removal.  The Board has  nominated  Edward B. Berger,  Robert M.
Kaufman,  Donald R. Ryan,  Derace L. Schaffer,  Roger L.  Chaufournier  and John
Pappajohn to fill these positions.

     The  discussion  below sets forth,  as of the record date, the names of the
nominees  and  their  ages,  a  brief   description  of  their  recent  business
experience,  including present occupations and employment, certain directorships
held by each and the year in which each became a director of the Company.

     The affirmative  vote of the holders of a plurality of the shares of Common
Stock of the Company  present in person or by proxy and  entitled to vote at the
Annual Meeting is required for the election of each director. Proxies granted by
stockholders  will be voted  individually for the election,  as directors of the
Company, of the persons listed below, unless a proxy specifies that it is not to
be voted in favor of a nominee for  director.  In the event any of the  nominees
listed  below shall be unable to serve,  it is  intended  that the proxy will be
voted for such other nominees as are designated by the Board of Directors.  Each
of the  persons  named  below has  indicated  to the Board of  Directors  of the
Company that they are available to serve.

The Board of  Directors  recommends  a vote  "FOR" the  election  of each of the
following nominees for director.

Nominees

     Edward B. Berger,  75. Mr. Berger is currently Chairman and Chief Executive
     Officer of Equity Acquisitions  Incorporated,  a position he has held since
     January  2004  Chairman of the Board of  Directors  of  Southwest  Business
     Systems,  Director  and  Chairman  of the Audit  Committee  of  CardSystems
     Solutions  and Director of Compass Bank of Tucson,  AZ. Mr. Berger has been
     admitted to practice law by the U.S.  Supreme Court,  New York Bar, Arizona
     Bar,  District of Columbia Bar, U.S.  District  Court-Arizona  and the U.S.
     Court of Appeals 9th Circuit.  Mr. Berger is currently an Adjunct Professor
     in Political  Science at Pima Community  College and is the Chairman of the
     MBA Advisory  Council at the University of Arizona.  Mr. Berger  received a
     Juris  Doctor  in Law from New York Law  School  and a  Masters  Degree  in
     Education as well as a B.A. in History and English from the  University  of
     Arizona.

     Robert M.  Kaufman,  55.  Mr.  Kaufman  is  currently  President  and Chief
     Executive Officer of Oakley Investments,  a position he held since November
     2002, and Director and Chairman of the Audit Committee of Berkshire  Income
     Realty.  From January 2000 through November 2002, Mr. Kaufman was the Chief
     Executive  Officer of MedEView,  Inc.,  from June 1996 though April 1999 he
     was President and then Chief  Executive  Officer of CareMatrix  Corporation
     and from  April  1999  through  December  1999 he was a  consultant  to the
     Company.    Prior   to   1996,    Mr.    Kaufman    spent   24   years   at
     PriceWaterhouseCoopers,  the last 15 years as a Partner  in the  firm.  Mr.
     Kaufman  received  a  Masters  in  Business   Administration  from  Cornell
     University and a Bachelor of Arts from Colby College.

                                       3


     Donald R. Ryan,  57. Mr. Ryan is currently  President  and Chief  Executive
     Officer of CareCore National, LLC, a position he held since September 2000.
     Until  August  2000,   Mr.  Ryan  was  President  of  Practice   Management
     Associates,   Inc.  Mr.  Ryan   received  a  Masters   Degree  in  Hospital
     Administration  from St. Louis University and a Bachelors of Arts Degree in
     Political Science with a minor in Economics from Providence College.

     Derace L. Schaffer,  M.D., 57. Dr.  Schaffer has been a Director of Patient
     Infosystems  since its inception in February 1995 and served as Chairman of
     the Board of Directors until November 2004. Dr. Schaffer is the founder and
     CEO of the Lan Group, a venture capital firm specializing in healthcare and
     high  technology  investments  which position he has held for more than the
     last five years.  He serves as a director  of Allion  Healthcare,  Inc.,  a
     public company. He received his postgraduate  radiology training at Harvard
     Medical School and Massachusetts General Hospital, where he served as Chief
     Resident. Dr. Schaffer is Clinical Professor of Radiology at the University
     of Rochester School of Medicine.

     Roger Louis  Chaufournier,  46 Mr.  Chaufournier has been the President and
     Chief  Executive  Officer of Patient  Infosystems  since  April 1, 2000 and
     served as Chairman of the Board of Directors since November 2004.  Prior to
     joining Patient  Infosystems,  Mr.  Chaufournier  was President of the STAR
     Advisory  Group,  a  healthcare  consulting  firm he founded in 1998.  From
     August 1996 to July 1999, Mr.  Chaufournier was the Chief Operating Officer
     of the Managed  Care  Assistance  Company,  a company  that  developed  and
     operated Medicaid health plans.  Managed Care Assistance  Company filed for
     protection  under the federal  bankruptcy  laws in June 2000.  From 1993 to
     1996, Mr.  Chaufournier  was Assistant Dean for Strategic  Planning for the
     Johns Hopkins University School of Medicine. In addition,  Mr. Chaufournier
     spent  twelve years in  progressive  leadership  positions  with the George
     Washington University Medical Center from 1981 to 1993.

     John  Pappajohn,   76.  Mr.  Pappajohn  has  been  a  Director  of  Patient
     Infosystems  since  its  inception  in  February  1995,  and  served as its
     Secretary and Treasurer  from inception  through May 1995.  Since 1969, Mr.
     Pappajohn has been the sole owner of Pappajohn Capital Resources, a venture
     capital firm and President of Equity Dynamics, Inc., a financial consulting
     firm,  both  located in Des Moines,  Iowa.  He serves as a director for the
     following public companies: Allion Healthcare,  Inc., MC Informatics,  Inc.
     and Pace Health Management Systems, Inc.

                                       4


                                   PROPOSAL 2
               APPROVAL OF THE AMENDMENT OF THE STOCK OPTION PLAN

     The Company's stockholders are being asked to approve the Third Amended and
Restated  Stock  Option  Plan of the  Company  which  (i)  expands  the class of
eligible  participants  to include  nominees  to the Board of  Directors  of the
Company and consultants engaged by the Company and (ii) increases from 36,000 to
50,000 the number of shares of Common Stock  underlying  the one-time grant of a
Non-Qualified Option to which non-employee directors or non-employee nominees of
the Board of Directors may be entitled.

Reasons for the Proposal

     Under the Second  Amended and  Restated  Stock  Option Plan as currently in
effect (the ("Stock Option  Plan"),  only Directors and employees of the Company
are  eligible to received  options.  In order for the Stock Option Plan to serve
its intended purpose of furnishing additional incentives to key personnel of the
Company,  upon whose judgment,  initiative and efforts the successful conduct of
the business of the Company  largely  depends,  and to strengthen the ability of
the Company to attract and retain in its employ,  as  consultants or as a member
of the Board of  Directors,  persons of training,  experience  and ability,  the
Board of Directors  feels it is in the best  interests to amend the Stock Option
Plan as  proposed.  Furthermore,  as the  duties,  responsibilities  and risk of
liability  for  independent   board  members  have  increased,   it  has  become
increasingly  challenging to identify and retain  qualified  persons to serve on
the Board of Directors.  The Company  believes that is very important to attract
and retain qualified and independent members to serve on its Board of Directors.
Accordingly,  the  Company  believes  that it is in the  best  interests  of the
Company and its shareholders to increase the one-time option incentive available
to  independent  board  members from options to acquire  36,000 shares of Common
Stock to options to acquire 50,000 shares of Common Stock.

Description of the Stock Option Plan and the Proposed Amendment

     The  following  is a summary  of the  Stock  Option  Plan and the  proposed
amendment. This summary does not purport to be complete, and is qualified in its
entirety by reference to the text of the Third Amended and Restated Stock Option
Plan, which is attached as Exhibit A to this Proxy Statement.

Purpose.  The Stock Option Plan is designed to furnish additional  incentives to
key employees,  directors, nominees and consultants of Patient Infosystems, upon
whose judgment, initiative and efforts the successful conduct of the business of
Patient  Infosystems  largely depends,  and to strengthen the ability of Patient
Infosystems to attract and retain in its employ,  or as a member of the Board of
Directors,  persons of training,  experience and ability.  The Stock Option Plan
presently authorizes the granting of options of up to 3,500,000 shares of common
stock  ("Options").  The Board of Directors  believes it is beneficial to expand
the class of eligible participants to include nominees to the Board of Directors
of the Company and consultants engaged by the Company, subject to the discretion
of the Board of  Directors,  and to  increase  from  36,000 to 50,000 the number
shares of common stock  underlying the one-time grant of a Non-Qualified  Option
to non-employee  directors or  non-employee  nominees of the Board of Directors,
which the Plan Administrator may grant in its sole discretion.

                                       5


Administration.  The Stock Option Plan is currently  administered  by either the
full Board of Directors or such  committee as may be  designated by the Board of
Directors  (the  "Committee").  In  administering  the Stock  Option  Plan,  the
Committee has the power to interpret its provisions and to prescribe,  amend and
rescind rules and regulations for its  administration,  to select individuals to
receive  grants,  to determine the terms and provisions of grants of options and
to make all other  determinations  necessary or advisable for  administration of
the Stock Option Plan.

Option Grants. The Stock Option Plan provides for the granting of both incentive
stock options (an "ISO") and nonqualified stock options (a "NQO").  NQO's may be
issued generally to any employee, director, nominees for director or consultants
of Patient  Infosystems or its subsidiaries.  ISO's may only be issued generally
to employees of Patient Infosystems and its subsidiaries,  and may not be issued
to any director. The Committee also determines the times at which options become
exercisable,  their transferability and the dates, not more than ten years after
the date of grant (five years in the case of optionees  holding more than 10% of
the combined  voting power of all classes of stock of Patient  Infosystems),  on
which  options will  expire.  The fair market value of the stock with respect to
which ISO's under the Stock Option Plan or any other plan of Patient Infosystems
first become  exercisable  may not exceed $100,000 in any year. The option price
of an ISO is to be at least 100% of the fair  market  value on the date of grant
(110% in the case of  optionees  holding  more than ten percent of the  combined
voting power of all classes of stock of Patient  Infosystems).  The Stock Option
Plan,  however,  permits  the  Committee  to grant NQO's at any  exercise  price
consistent  with the  purposes  of the Stock  Option  Plan,  whether or not such
exercise  price is equal to the fair  market  value of the  stock on the date of
grant of the NQO. NQO's with an exercise price of less than fair market value on
the date of grant  will not  qualify  as  performance-based  compensation  under
Section 162(m) of the Internal Revenue Code of 1986, as amended (the "Code") and
so any  compensation  expense  generated by the exercise of such an option would
not be deductible by Patient Infosystems if the optionee is a "covered employee"
who is paid  compensation  from  Patient  Infosystems  in an amount in excess of
$1,000,000  in the year of exercise.  Options may be exercised by the payment of
the exercise price in cash or by certified or bank check. Under the Stock Option
Plan as currently in effect,  non-employee  directors  are entitled to receive a
one-time grant of a NQO to purchase  36,000 shares at an exercise price equal to
fair market  value per share on the date of his or her  initial  election to the
Board of Directors.  Under the proposed  Third Amended and Restated Stock Option
Plan non-employee nominees to the Board of Directors,  at the sole discretion of
the Committee,  may receive a one-time grant of a NQO to purchase  50,000 shares
at an exercise  price equal to fair market value per share on the date of his or
her initial  nomination  to the Board of  Directors.  In the event such one-time
grant  of a NQO is not  granted  to a  non-employee  nominee  to  the  Board  of
Directors upon the date of his or her  nomination,  such NQO to purchase  50,000
shares will automatically be granted upon the date of such nominee's election to
the Board of Directors.  Such NQO is  exercisable  only during the  non-employee
director's term and  automatically  expires on the date such director's  service
terminates.

Income Tax  Consequences.  Under present law the federal income tax treatment of
stock options under the Stock Option Plan is generally as follows:

                                       6


Incentive Stock Options.  For regular income tax purposes,  an optionee will not
realize  taxable  income upon either the grant of an ISO or its  exercise if the
optionee  has been an employee of Patient  Infosystems  or a  subsidiary  at all
times  from the date of grant to a date not more than  three  months  before the
date of exercise.  The difference  between the fair market value of the stock at
the date of exercise and the exercise price of an ISO, however,  will be treated
as an  item of tax  preference  in the  year of  exercise  for  purposes  of the
alternative  minimum tax. If the shares  acquired upon an exercise of an ISO are
not  disposed  of by the  optionee  within  two years  from the date of grant or
within one year from the date of exercise,  any gain  realized upon a subsequent
sale of the shares will be taxable as a capital gain. In that case,  the Company
will not be entitled to a deduction in connection with the grant or the exercise
of the ISO or the  subsequent  disposition  of the shares by the  optionee.  The
amount of gain or loss  realized upon such a sale or other  disposition  will be
measured by the difference  between the amount realized and the earlier exercise
price of the ISO (the optionee's basis in the stock).  If the optionee  disposes
of the  shares  within two years from the date of grant of the ISO or within one
year from the date of exercise of the ISO,  the optionee  will realize  ordinary
income in an amount  equal to the excess of the fair market  value of the shares
at the date of exercise (or the amount  realized on  disposition,  if less) over
the option price, and the Company will be allowed a corresponding  deduction. If
the amount  realized on the  disposition  exceeds  the fair market  value of the
shares at the date of exercise the gain on  disposition  in excess of the amount
treated as ordinary  income will be treated as a capital gain.  Any such capital
gain will be a mid-term  capital gain if the optionee  holds the shares for more
than one year,  but not more than 18 months,  from the date of exercise.  If the
optionee holds the shares for more than 18 months from the date of exercise, any
such gain will be a long-term capital gain.

Nonqualified  Stock Options.  An optionee will not realize income upon the grant
of a  nonqualified  option.  Upon the  exercise  of a  nonqualified  option,  an
optionee will be required to recognize ordinary income in an amount equal to the
excess  of the fair  market  value at the date of  exercise  of the NQO over the
option  price.  Any  compensation  includable in the gross income of an employee
with  respect  to a NQO  will be  subject  to  appropriate  federal  income  and
employment  taxes. The Company will be entitled to a business expense  deduction
in the  same  amount  and at the  same  time as  when  the  optionee  recognizes
compensation income. Upon a subsequent sale of the stock, any amount realized in
excess of such fair  market  value  will  constitute  a capital  gain.  Any such
capital gain will be a mid-term  capital  gain if the optionee  holds the shares
for more than one year, but not more than 18 months,  from the date of exercise.
If the  optionee  holds the  shares  for more  than 18  months  from the date of
exercise,  any such  gain  will be a  long-term  capital  gain.  In the  limited
circumstances  in  which an  officer  who is  subject  to  Section  16(b) of the
Securities  Exchange Act of 1934,  as amended (the "1934 Act")  exercises a NQO,
which  exercise is not exempt under Section  16(b),  no income is recognized for
federal income tax purposes at the time of exercise unless the optionee makes an
election  under  Section  83(b) of the Code  within  30 days  after  the date of
exercise,  in which case the rules described in the second  preceding  paragraph
would apply.  Where such an election is not made,  the optionee  will  recognize
ordinary  income on the first  date that sale of such  shares  would not  create
liability  under  Section  16(b)  of the 1934 Act  (this is  generally,  but not
necessarily,  six  months  after  the date of  exercise).  The  ordinary  income
recognized  to such an optionee  will be the excess,  if any, of the fair market
value of shares on such later date over the option exercise price. The foregoing
discussion  does not purport to be a complete  analysis of all the potential tax
consequences  relevant to recipients of options or to Patient Infosystems or its
subsidiaries.  The above  discussion  does not take into  account  the effect of
state and local tax laws. Moreover,  no assurance can be given that legislative,
administrative, regulatory or judicial changes or interpretations will not occur
which could modify such analysis.  In addition,  an individual's  particular tax
status and his other tax  attributes  may result in different  tax  consequences
from those described above. Therefore,  any participant in the Stock Option Plan
should consult with his own tax adviser  concerning the tax  consequences of the
grant,  exercise and surrender of such options and the  disposition of any stock
acquired pursuant to the exercise of such options.

                                       7


Amendments.  The Committee may amend the Stock Option Plan at any time,  but may
not, without prior stockholder approval,  increase the maximum number of options
that  may  be  granted  thereunder;  change  the  eligibility  requirements  for
individuals  entitled to receive  options  under the Stock Option Plan, or cause
ISO's granted or to be granted under the Stock Option Plan to fail to qualify as
ISO's under the Code.

Vote Required.  The affirmative vote of a majority of the outstanding  shares of
common  stock voted in person or by proxy at the Annual  Meeting is required for
approval of the amendments to the Stock Option Plan.

     The Board of  Directors  concluded  that the  amendment of the Stock Option
Plan is in the best interests of the Company and its stockholders.  The Board of
Directors  has  unanimously  approved the amendment of the Stock Option Plan and
unanimously  recommends  that you vote "FOR" the  amendment  of the Stock Option
Plan.


                                   PROPOSAL 3
                         RATIFICATION OF APPOINTMENT OF
                              INDEPENDENT AUDITORS

     On  April  28,  2004,  the  Board of  Directors  of the  Company  appointed
McGladrey & Pullen LLP as its independent  certified public  accountants for the
fiscal year ending  December 31, 2004.  Although the  appointment of auditors is
not required to be submitted to a vote of  stockholders,  the Board of Directors
believes  that it is  appropriate  as a matter  of policy  to  request  that the
stockholders  ratify the appointment.  If the stockholders should not ratify the
appointment,   the  Audit  Committee  will   investigate  the  reasons  for  the
stockholders'   rejection  and  the  Board  of  Directors  will  reconsider  the
appointment. It is expected that a representative of McGladrey & Pullen LLP will
be present at the meeting to respond to appropriate  questions and will be given
the opportunity to make a statement if he or she desires to do so.

     The independent  public  accounting firm utilized by the Company during the
year ended  December 31, 2003 was  Deloitte & Touche LLP.  Deloitte & Touche LLP
resigned as the Company's independent  accountants on April 21, 2004. Deloitte &
Touche LLP's  reports on the financial  statements  for the past two years ended
December  31,  2003 and 2002  contained  no  adverse  opinion or  disclaimer  of
opinion.  Deloitte & Touche LLP's reports on the financial  statements contained
an  explanatory  paragraph  expressing  substantial  doubt  about the  Company's
ability to continue as a going  concern.  In connection  with its audits for the
two most recent fiscal years ended  December 31, 2003 and 2002 and through April
21, 2004,  there have been no  disagreements  with  Deloitte & Touche LLP on any
matter of accounting principles or practices, financial statement disclosure, or
auditing  scope  or  procedure,  which  disagreements  if  not  resolved  to the
satisfaction  of Deloitte & Touche LLP would have caused them to make  reference
thereto in their report on the financial  statements  for such years.  It is not
expected  that a  representative  from  Deloitte & Touche will be present at the
meeting.

     The  affirmative  vote of the holders of a majority of the shares of Common
Stock of the Company  present in person or by proxy and  entitled to vote at the
Annual Meeting is required for the  ratification and approval of the appointment
of auditors.

                                       8


     The  Board  of  Directors  recommends  a  vote  "FOR"  ratification  of the
appointment of McGladrey & Pullen LLP as the Company's  independent auditors for
the fiscal year ending December 31, 2004.

Relationship with Independent Auditors

     Audit  services  performed  by  Deloitte & Touche LLP for fiscal  year 2003
consisted of the examination of the Company's financial  statements and services
related to filings with the Securities and Exchange Commission ("SEC").

Audit Fees

     The  aggregate  fees  billed  by  Deloitte  & Touche  LLP for  professional
services rendered in connection with the audit of the Company's annual financial
statements for the year ended December 31, 2003, and the review of the Company's
quarterly  financial  statements for the quarters ended March 31, 2003, June 30,
2003 and September 30, 2003, were  approximately  $83,750 as compared to $72,960
for the same respective periods of 2002.

Audit-Related Fees

     The  aggregate  fees  billed  by  Deloitte  & Touche  LLP for  professional
services  rendered  related  to the  audit  of the  Company's  annual  financial
statements  for the year ended  December 31, 2003 were  approximately  $5,440 as
compared to $5,743 for the year ended December 31, 2002.

Financial Information Systems Design and Implementation Fees

     The  aggregate  fees  billed  by  Deloitte  & Touche  LLP for  professional
services   rendered  in  connection   with   information   systems   design  and
implementation during the two most recent fiscal years were approximately $0.

Tax Fees

     Delotitte & Touche LLP billed the Company  approximately $5,250 and $14,863
during the fiscal years ended 2003 and 2002,  respectively,  for tax  compliance
services.

All Other Fees

     The aggregate fees for all other services rendered by Deloitte & Touche LLP
for the year ended December 31, 2003 were  approximately  $45,000 as compared to
$5,815 for the year ended December 31, 2002.

     The Audit  Committee  considers at least annually  whether the provision of
non-audit  services  by  Deloitte & Touche LLP is  compatible  with  maintaining
auditor independence.

                                       9


Pre-Approval of Audit and Permissible Non-Audit Services

     The  Audit  Committee  pre-approves  all audit  and  permissible  non-audit
services provided by the independent auditors.  These services may include audit
services,  audit-related  services,  tax services and other services.  The Audit
Committee has adopted a policy for the pre-approval of services  provided by the
independent auditors.  Under the policy,  pre-approval is generally provided for
up to one year and any pre-approval is detailed as to the particular  service or
category of services and is subject to a specific budget. In addition, the Audit
Committee may pre-approve  particular services on a case-by-case basis. For each
proposed  service,  the  independent  auditor is  required  to provide  detailed
back-up  documentation  at the  time of  approval.  All  audit  and  permissible
non-audit  services  provided  by  Deloitte & Touche LLP to the  Company for the
fiscal years ended 2003 and 2002 were approved by the Audit Committee.

REPORT OF THE AUDIT COMMITTEE

     The Audit Committee oversees the Company's  financial  reporting process on
behalf of the Board of Directors.  Management has the primary responsibility for
the financial  statements  and the reporting  process,  including the systems of
internal  controls.  We reviewed with Deloitte & Touche LLP, who are responsible
for expressing an opinion on the conformity of our audited financial  statements
with generally accepted accounting principles, and with management, our critical
accounting policies, and the clarity of disclosures in the financial statements.
Our reviews included  discussions with Deloitte & Touche LLP of matters required
to be discussed pursuant to Statement on Auditing Standards No. 61. In addition,
we discussed  with Deloitte & Touche LLP matters  relating to its  independence,
including a review of both audit and non-audit fees and disclosures  made to the
Audit  Committee  pursuant to  Independence  Standards  Board Standard No. 1 and
considered  the   compatibility   of  non-audit   services  with  the  auditors'
independence.  Furthermore,  we  discussed  the  Company's  critical  accounting
policies with management and Deloitte & Touche LLP.

     We  discussed  with  Deloitte & Touche LLP the  overall  scope and plans of
their audits.  We met with  Deloitte & Touche LLP, as the Company's  independent
auditors,  with and  without  management  present,  to discuss  results of their
audits,  their evaluation of the Company's  internal  controls,  and the overall
quality of the  Company's  financial  reporting.  We held five  meetings  during
fiscal 2003.

     Relying  on both the  reviews  and  discussions  referred  to above and our
review of the  Company's  audited  financial  statements  for  fiscal  2003,  we
recommended  to the Board that the audited  financial  statements be included in
the Annual  Report on Form 10-KSB for the fiscal year ended  December  31, 2003,
for filing with the Securities and Exchange Commission.

                                                 John Pappajohn
                                                 Dr. Derace L.Schaffer
                                                 AUDIT COMMITTEE

                                       10


                            GOVERNANCE OF THE COMPANY

MEETINGS OF THE BOARD AND COMMITTEES

     During the 2003  fiscal  year there  were  seven  meetings  of the Board of
Directors.  Each Director attended at least six of the aggregate total number of
the meetings of the Board of Directors held during the year.

     The  Company  does not have a policy  regarding  Directors'  attendance  at
annual meetings and one Director attended the prior year's annual meeting.

     The Board of Directors of the Company has  appointed  two  committees:  the
Audit Committee and the Compensation Committee.

     The Audit  Committee,  which held five  meetings  during  fiscal year 2003,
periodically  reviews the Company's  auditing  practices and  procedures,  makes
recommendations  to management or to the Board of Directors as to any changes to
such practices and procedures  deemed necessary from time to time to comply with
applicable  auditing rules,  regulations and practices,  reviews all Form 10-KSB
Annual and 10-QSB  interim  reports and  retains  independent  auditors  for the
Company.

     Through November 2004, the Audit Committee  consisted of John Pappajohn and
Dr. Derace  Schaffer.  The Board of Directors has determined that John Pappajohn
qualified as an audit committee financial expert as that term is defined in Item
401(e)  of  Regulation  S-B.  Mr.  Pappajohn  nor  Dr.  Schaffer   qualified  as
"independent"  as that term is used in Item  7(d)(3)(iv)  of Schedule 14A of the
Securities  Exchange Act of 1934.  On November 17, 2004,  the Board of Directors
appointed  Edward B.  Berger,  Robert M. Kaufman and Donald Ryan to serve as the
Audit Committee.  Mr. Kaufman now serves as Chairman of the Audit Committee. The
Board of  Directors  has  determined  that  Mr.  Kaufman  qualifies  as an audit
committee  financial expert as that term is defined in Item 401(e) of Regulation
S-B. Each of Mr. Berger,  Mr. Kaufman and Mr. Ryan qualifies as "independent" as
that term is used in Item 7(d)(3)(iv) of Schedule 14A of the Securities Exchange
Act of 1934

     The  Board of  Directors  has  adopted  a  written  charter  for the  Audit
Committee, which is annexed hereto as Exhibit B.

     The Audit Committee meets with the Company's independent auditors quarterly
and  reviews  the  scope of the audit  performed  by the  Company's  independent
auditors.  The Audit Committee and the Company's independent auditors review the
Company's accounting principles and internal accounting controls. See "Report of
the Audit Committee" contained in this proxy statement. The members of the Audit
Committee are all non-employee directors.

     The Compensation  Committee met twice during 2003, and  periodically  makes
recommendations  to the  Board of  Directors  concerning  the  compensation  and
benefits  payable  to  the  Company's   executive   officers  and  other  senior
executives.  The Compensation  Committee also administers the Company's Employee
Stock Option Plan. Through November 2004, the Compensation  Committee  consisted
of John  Pappajohn  and Dr.  Derace  Schaffer.  On November 17, 2004,  the Board
appointed Mr. Berger, Mr. Pappajohn,  Dr. Schaffer and Mr. Chaufournier to serve
as the  Compensation  Committee.  Mr.  Berger  now  serves  as  Chairman  of the
Compensation Committee.

                                       11


     Prior  to  November  17,  2004,  the  Board  did not  maintain  a  separate
Nominating  Committee.  On November 17, 2004, the Board appointed Dr.  Schaffer,
Mr. Berger and Mr. Pappajohn to serve as the Nominating Committee.  Dr. Schaffer
now serves as Chairman of the Nominating Committee. The Board has yet to adopt a
formal  written  charter  relating to its  nominating  procedures  but is in the
process of formulating a formal written charter for adoption in the near future.
The  Board  of  Directors  would  carefully  consider  all  director  candidates
recommended by the Company's  stockholders,  and the Board does not and will not
evaluate  such  candidate  recommendations  any  differently  from  the  way  it
evaluates other candidates.  In its evaluation of each proposed  candidate,  the
Board considers many factors  including,  without  limitation,  the individual's
experience, character, demonstrations of judgment and ability, and financial and
other special  expertise.  Any shareholder who wishes to recommend an individual
as a  nominee  for  election  to the  Board  of  Directors  should  submit  such
recommendation  in  writing  to the  Chief  Executive  Officer  of the  Company,
together  with  information  regarding  the  experience,  education  and general
background  of the  individual.  Such  recommendation  should be provided to the
Company no later than the deadline for submission of shareholder  proposals with
respect to the  annual  meeting at which such  candidate,  if  nominated  by the
Board, would be proposed for election.


COMMUNICATIONS WITH THE BOARD OF DIRECTORS

     The  Company  encourages  stockholder  communications  with  the  Board  of
Directors.  The  Board of  Directors  does not  believe  a  formal  process  for
stockholders  to send  communications  to the Board of  Directors  is  necessary
because all shareholder  communications will be circulated to all members of the
Board  and the  Board  does  not  screen  shareholder  communications.  All such
communications should be directed to Roger L. Chaufournier,  the Chief Executive
Officer of the  Company,  who will  circulate  them to the other  members of the
Board.


COMPENSATION OF DIRECTORS

     Directors of the Company do not receive cash compensation for their service
on the Company's Board of Directors.  However,  all Directors are reimbursed for
expenses  incurred in  connection  with  attending  meetings,  including  travel
expenses to such meetings.

     The Company's  directors are eligible to participate in the Company's Stock
Option  Plan.  Pursuant  to the Stock  Option  Plan (as  proposed  at the Annual
Meeting),  non-employee  directors of the Company  receive a one-time grant of a
non-qualified  stock option to purchase  50,000 shares of the  Company's  Common
Stock at an exercise  price equal to fair market  value per share on the date of
their initial election to the Company's Board of Directors.  Such  non-qualified
stock option vests as to 20% of the option grant on the first anniversary of the
grant,  and 20% on each subsequent  anniversary,  is exercisable only during the
non-employee  director's  term  and  automatically  expires  on  the  date  such
director's service  terminates.  Upon the occurrence of a change of control,  as
defined in the Stock Option Plan, all outstanding  unvested options  immediately
vest.

CODE OF ETHICS

     The Board of  Directors  of the Company has adopted a code of ethics  which
defines the ethical  principles which govern the conduct of all senior officers.
Such  senior  officers  include the Chief  Executive  Officer,  Chief  Operating
Officer, Chief Financial Officer, Principal Accounting Officer and Controller. A
copy of the  Company's  Code of Ethics  will be  provided  without  charge  upon
written request to: Patient Infosystems,  Inc., 46 Prince Street, Rochester, New
York, 14607, Attention: Yvonne Milligan-Prince.

                                       12


                    SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
                              OWNERS AND MANAGEMENT

     The following table sets forth certain information regarding the beneficial
ownership of the shares of the  Company's  Common Stock as of November 30, 2004,
(i) by each person the Company knows to be the beneficial owner of 5% or more of
the outstanding  shares of Common Stock,  (ii) the Chief  Executive  Officer and
each named  executive  officer listed in the Summary  Compensation  Table below,
(iii) each  director  and  nominee  for  director  of the  Company  and (iv) all
executive  officers and directors of the Company as a group.  As of November 30,
2004, there were outstanding  9,683,150 shares of Common Stock, 75,000 shares of
Series C Convertible Preferred Stock,  convertible into 750,000 shares of Common
Stock, and 840,118 shares of Series D Convertible  Preferred Stock,  convertible
into 8,401,180 shares of Common Stock.



                                                                Shares         Percentage
                                                             Beneficially     Beneficially
     Beneficial Owner(1)                                        Owned             Owned
                                                                         
John Pappajohn(2)                                            8,306,757            55.04%
Principal Life Insurance(3)                                  3,551,490            26.93%
  801 Grand Ave.
  Des Moines, IA 50392
Derace L. Schaffer(4)                                          926,470            14.14%
American Caresource Corporation                              1,100,000            11.41%
  17400 Dallas Parkway
  Dallas, TX 75287
Crestview Capital Master, LLC                                  500,000             5.19%
  95 Revere Drive, Suite A
  Northbrook, IL 60062
Gibralt Capital Corp.                                          500,000             5.19%
  2600-1075 W. Georgia Street
  Vancouver, BC V6E3C9 Canada
Roger Louis Chaufournier(5)                                    273,332             2.76%
Edward B. Berger(6)                                            145,060             1.49%
Christine St. Andre(7)                                         145,000             1.48%
Kent A. Tapper(8)                                               86,333             0.89%
Robert M. Kaufman(9)
Donald R. Ryan(10)

All directors and executive officers as a group (8 persons) 10,142,385            61.94%

Total Shares Outstanding as of November 30, 2004             9,638,150


(1)  Unless  otherwise  noted,  the address of each of the listed persons is c/o
     the Company at 46 Prince Street, Rochester, New York 14607.

                                       13


(2)  Includes 30,000 shares held by Halkis, Ltd., a sole proprietorship owned by
     Mr. Pappajohn,  30,000 shares held by Thebes,  Ltd., a sole  proprietorship
     owned by Mr.  Pappajohn's  spouse and 30,000  shares  held  directly by Mr.
     Pappajohn's  spouse. Mr. Pappajohn  disclaims  beneficial  ownership of the
     shares  owned by Thebes,  Ltd.  and by his  spouse.  Includes  an option to
     purchase 3,000 shares of Common Stock, a warrant to purchase 816,667 shares
     of  Common  Stock  and a  warrant  to  purchase  28,220  shares of Series D
     Convertible  Preferred  Stock which is  convertible  into 282,200 shares of
     Common  Stock  which  are  either  currently  exercisable  or which  become
     exercisable  within 60 days of November 30, 2004. Also included are 110,000
     shares of Common Stock  issuable  upon the  conversion  of 11,000 shares of
     Series C Convertible  Preferred Stock and 4,352,330  shares of Common Stock
     issuable  upon the  conversion  of 435,233  shares of Series D  Convertible
     Preferred Stock beneficially owned as of November 30, 2004.

(3)  Includes  3,551,490  shares of Common Stock issuable upon the conversion of
     355,149 shares of Series D Convertible  Preferred Stock  beneficially owned
     as of November 30, 2004.

(4)  Includes 12,000 shares held by Dr. Schaffer's children. Also includes 3,000
     shares which are  issuable  upon the  exercise of options,  183,333  shares
     which are issuable  upon the exercise of warrants to purchase  Common Stock
     and 192,800  shares of Common Stock issuable upon the exercise of a warrant
     to purchase 19,280 shares of Series D Convertible  Preferred Stock that are
     either currently  exercisable or which become exercisable within 60 days of
     November  30,  2004,  250,000  shares of  Common  Stock  issuable  upon the
     conversion  of 25,000 shares of Series C  Convertible  Preferred  Stock and
     53,180 shares of Common Stock  issuable upon the conversion of 5,318 shares
     of Series D Convertible  Preferred Stock  beneficially owned as of November
     30, 2004.

(5)  Includes  options to purchase  273,332  shares  which are either  currently
     exercisable  or  which  become  exercisable  within  60 days of the date of
     November 30, 2004.  Does not include  160,000 shares subject to outstanding
     options that are not exercisable within 60 days of November 30, 2004.

(6)  Includes  59,523 shares of Common Stock held by Tucson  Traditions LLC. Mr.
     Berger is an affiliate of Tucson  Traditions  LLC and disclaims  beneficial
     ownership  of its  shares.  Also  includes  95,060  shares of Common  Stock
     issuable  upon the  conversion  of 9,506  shares  of  Series D  Convertible
     Preferred  Stock  beneficially  owned as of  November  30,  2004.  Does not
     include  50,000  shares  subject  to  outstanding   options  that  are  not
     exercisable within 60 days of November 30, 2004.

(7)  Includes  options to purchase  145,000  shares  which are either  currently
     exercisable  or  which  become  exercisable  within  60 days of the date of
     November 30, 2004.  Does not include  80,000 shares  subject to outstanding
     options that are not exercisable within 60 days of November 30, 2004.

(8)  Includes  options to  purchase  86,333  shares  which are either  currently
     exercisable  or which  become  exercisable  within 60 days of November  30,
     2004.  Does not include 50,000 shares  subject to outstanding  options that
     are not exercisable within 60 days of November 30, 2004.

                                       14



(9)  Does not include 50,000 shares subject to outstanding  options that are not
     exercisable within 60 days of November 30, 2004.

(10) Does not include 50,000 shares subject to outstanding  options that are not
     exercisable within 60 days of November 30, 2004.


                             EXECUTIVE COMPENSATION

The following table sets forth  information  concerning the annual and long-term
compensation  for services in all  capacities to the Company and its  subsidiary
for each of the fiscal years ended  December  31, 2003,  2002 and 2001 for those
persons who were at December 31, 2003, (i) the Chief Executive  Officer and (ii)
the other executive officers of the Company who received  compensation in excess
of $100,000 during the fiscal year ended December 31, 2003 (the "named executive
officers"):




                           Summary Compensation Table
                                                                                      Long-Term
                                                                                     Compensation
                                                                                       Awards
                                                       Annual Compensation            Securities
Name and Principal Position                    Year        Salary         Bonus  Underlying Options (#)
---------------------------                    ----        ------         -----  ----------------------
                                                                          
Roger L. Chaufournier, President and Chief   2003          $219,611      $25,385            -
Executive Officer                            2002           180,841            -            -
                                             2001           196,502            -      200,000

Christine St. Andre, Vice President, Chief   2003          $184,050      $22,212            -
Operating Officer                            2002           157,512            -            -
                                             2001           171,893            -      150,000

Kent A. Tapper, Vice President, Financial    2003          $124,154      $14,913            -
Planning                                     2002           107,942            -            -
                                             2001           116,628            -      100,000


No stock  options  were  exercised by the Chief  Executive  Officer or the named
executive officers of the Company during 2003.

     The following table sets forth certain  information  regarding  unexercised
options held by the Chief Executive Officer and the named executive  officers of
the Company at December  31,  2003.  The table does not give effect to grants of
options that occurred after December 31, 2003. For additional  information  with
respect to these grants, see "Stock Option Plan".

                                       15




                     Aggregated Option Exercises during 2003
                     and Option Values on December 31, 2003

                       Number of Securities Underlying      Value of Unexercised
                           Unexercised Options at          In-the-Money Options at
                            December 31, 2003(#)           December 31, 2003($)(1)
                            --------------------           -----------------------
Name                  Exercisable      Unexercisable   Exercisable      Unexercisable
----                  -----------      -------------   -----------      -------------
                                                                       
Roger L. Chaufournier      23,415             9,917        $1,500                1,000
Christine St. Andre        17,499             7,501         1,125                  750
Kent A. Tapper              9,582             1,751         3,187                  263


(1)  Calculated based upon $2.40 market value of the underlying securities as of
     December 31, 2003.


STOCK OPTION PLAN

     The  Company's  Amended and  Restated  Stock  Option Plan (the  "Plan") was
adopted by the Board of  Directors  and  stockholders  in 1995 and amended as of
December  2003. As of December 3, 2004,  up to 3,500,000  shares of Common Stock
are authorized and reserved for issuance under the Plan. Under the Plan, options
may be granted in the form of incentive stock options  ("ISOs") or non-qualified
stock  options  ("NQOs")  from  time to time to  salaried  employees,  officers,
directors and  consultants  of the Company,  as  determined by the  Compensation
Committee of the Board of Directors.  The Compensation  Committee determines the
terms and conditions of options  granted under the Plan,  including the exercise
price. The Plan provides that the Committee must establish an exercise price for
ISOs  that is not less than the fair  market  value per share at the date of the
grant.  However,  if ISOs are  granted  to persons  owning  more than 10% of the
voting stock of the Company,  the Plan provides that the exercise price must not
be less than 110% of the fair  market  value per share at the date of the grant.
The Plan also provides for a  non-employee  director to be entitled to receive a
one-time  grant of a NQO to purchase  36,000  shares  (subject to an increase to
50,000 at the Annual  Meeting) at an exercise  price equal to fair market  value
per  share on the date of  their  initial  election  to the  Company's  Board of
Directors.  Such NQO is exercisable only during the non-employee director's term
and automatically  expires on the date such director's service terminates.  Each
option,  whether an ISO or NQO,  must expire within ten years of the date of the
grant.

                                       16


     As of November  30,  2004,  options to acquire  1,752,244  shares of Common
Stock have been granted to employees and directors of the Company. The following
table sets forth information regarding the number of options outstanding and the
exercise price of these options.

Number of Options Outstanding
     at November 30, 2004       Exercise Price
     --------------------       --------------
                  416                $1.08
                3,000                $1.67
              150,000                $1.80
               43,748                $2.25
            1,325,000                $2.28
              184,500                $2.80
               12,500                $6.00
                6,000                $8.33
                6,417               $16.50
                2,500               $22.56
               16,666               $24.72
                  789               $29.26
                  708               $33.00

     Of these options,  92,744 of the options  granted before  December 31, 2003
were fully vested,  1,341,000 were granted on January 9, 2004,  453,000 of which
vested  immediately.  The remaining  options and all other options granted under
the Plan  vest as to 20% of the  option  grant on the first  anniversary  of the
grant, and 20% on each subsequent anniversary.

                                       17


                      Equity Compensation Plan Information

     The following table gives information with respect to the equity securities
that are authorized for issuance under Patient  Infosystems'  compensation plans
as of  December  31,  2003.  The table does not  include  information  about the
proposed  amendment to the Second Amended and Restated Stock Option Plan that is
being submitted for stockholder approval at the Annual Meeting.




                                                                                             Number of securities
                                                                                            remaining available for
                                   Number of Securities to        Weighted-average           future issuance under
                                   be issued upon exercise        exercise price of        equity compensation plans
                                   of outstanding options,      outstanding options,         (excluding securities
Plan Category                        warrants and rights         warrants and rights          reflected in column)
-------------------------------    -------------------------    ------------------------    ---------------------------
Equity compensation plans
                                                                                                  
approved by security holders               1,752,244                     $2.66                       1,725,750
-------------------------------    -------------------------    ------------------------    ---------------------------
Equity compensation plans not
approved by security holders               1,663,450                     $1.53                               -
-------------------------------    -------------------------    ------------------------    ---------------------------
Total                                      3,415,694                     $2.11                       1,725,750



EMPLOYMENT CONTRACTS AND CHANGE-IN-CONTROL PROVISIONS

There are no employment agreements with any of the Company's executive officers.

REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

     In January 2003, the Compensation Committee restored the executive officers
salary to the same level they had been prior to a 10%  reduction in salary which
took  effect in October of 2001.  In August of 2003 the  Compensation  Committee
granted a salary  increase and a bonus which  equaled the amount of salary which
had been given up by the  executive  officers  between  October 2001 and January
2003.

     The  Compensation  Committee  evaluates the  performance  of each executive
officer of the  Company  in the  context  of the goals and  challenges  that the
Company faces over the next year. The  determinations as to salary and bonus are
made in a  context  of the  challenges  faced  in the  Company,  the  individual
performance  of the  individual  and the salaries of executives  at  comparative
companies in the Company's  industry.  Compensation for the Company's  Executive
Officers was determined in light of the responsibilities  involved in commencing
the Company's business  operations,  developing its initial and ongoing customer
relationships and negotiating with the Company's investment bankers.

                                                          Dr. Derace L. Schaffer
                                                                  John Pappajohn
                                                          COMPENSATION COMMITTEE

                                       18


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The Compensation  Committee consisted of Derace Schaffer and John Pappajohn
for the fiscal year ended December 31, 2003. Neither of these individuals was at
any time during fiscal year 2003 or any other time an officer or employee of the
Company.  No  executive  officer  of  the  Company  serves  as a  member  of the
compensation  committee  of any  other  entity  that  has one or more  executive
officers serving as a member of the Company's Board of Directors or Compensation
Committee.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     In December 1999,  Patient  Infosystems  established a credit  facility for
$1,500,000  guaranteed by Derace Schaffer and John  Pappajohn,  two directors of
the  Company.  In March 2000,  the facility was  increased by  $1,000,000  under
substantially the same terms, also guaranteed by the same Board members.

     On March 28, 2001, the Company  entered into an Amended and Restated Credit
Agreement with Wells Fargo Bank Iowa, N.A. ("Wells  Fargo"),  which extended the
term of the Company's credit facility to March 31, 2002 under  substantially the
same terms. Dr. Schaffer and Mr. Pappajohn guaranteed this extension.

     On March 28, 2002,  Wells Fargo extended the term of the credit facility to
March  31,  2003  under  substantially  the same  terms.  Dr.  Schaffer  and Mr.
Pappajohn also guaranteed this extension.

     On June 28, 2002,  the Company and Wells Fargo agreed on an addendum to the
Amended and Restated  Credit  Agreement  which extends the credit facility by an
additional  $500,000,  increasing the total credit  facility to $3,000,000.  Mr.
Pappajohn and Dr. Schaffer also guaranteed this extended credit facility.

     On March 28, 2003,  Wells Fargo extended the term of the credit facility to
January  2, 2004  under  substantially  the same  terms.  Dr.  Schaffer  and Mr.
Pappajohn also guaranteed this extension.

     Prior to December 31, 2003, the Company had borrowings  from Mr.  Pappajohn
and Dr. Schaffer. At December 31, 2002, such borrowings totaled $5,077,500.  The
Company borrowed an additional $150,000 from these directors during 2003.

     On December 31, 2003, the Company converted $4,482,500 in debt and $438,099
of accrued  interest owed to Mr. Pappajohn and Dr. Schaffer into common stock by
issuing  2,928,986  shares of the Company's  common stock using a value of $1.68
per common share.  Additionally  on December 31, 2003, Mr.  Pappajohn  agreed to
convert his  remaining  debt of $745,000 and accrued  interest of $711,110  into
145,611 shares of the Company's Series D Convertible  Preferred Stock at a price
of $10.00 per preferred share.

     Between April 2003 and January 2004,  the Company  issued 840,118 shares of
Series D 9% Cumulative  Convertible Preferred Stock ("Series D Preferred Stock")
under the terms of the Note and Stock  Purchase  Agreement  dated April 11, 2003
and amended on  September  10, 2003.  These shares can be converted  into common
stock at a rate of 10 shares of  common  stock to 1 share of Series D  Preferred
Stock. Each share of Series D Preferred Stock has voting rights equivalent to 10
shares of common stock. John Pappajohn and Derace Schaffer, members of the Board
of Directors of the Company, hold 435,233 and 5,318 shares of Series D Preferred
Stock respectively.

                                       19


     In January 2004, Patient Infosystems  borrowed $200,000 from Mr. Pappajohn,
a director  of the  Company,  in  exchange  for an  unsecured  note that bore no
interest if repaid on or before March 31, 2004. The note was repaid on March 29,
2004 and bore no interest as of that date.

     On December 31, 2003,  the Company  entered into the Third  Addendum to the
Second Amended and Restated  Credit  Agreement with Well Fargo Bank Iowa,  N.A.,
which extended the term of the $3,000,000  credit facility to July 31, 2005. Dr.
Schaffer and Mr. Pappajohn, directors of the Company, guaranteed this extension.
In consideration of their  guarantees,  in February 2004, the Company granted to
Dr.  Schaffer  and Mr.  Pappajohn  warrants to purchase an  aggregate  of 47,500
shares of Series D Convertible  Preferred  Stock,  which are convertible into an
aggregate  of  475,000  shares of the  Company's  common  stock for  $10.00  per
preferred  share.  The Company  valued these  warrants at  $1,085,375  using the
Black-Scholes  method. The value of these warrants was recorded as unearned debt
issuance costs and will be amortized as financing  costs over the nineteen month
period of the loan guarantee.

     On September 21, 2004, the Company  entered into the Fourth Addendum to the
Second Amended and Restated  Credit  Agreement with Well Fargo Bank Iowa,  N.A.,
which increased the amount of the credit facility to $7,000,000 and extended the
term to July 31, 2006. Dr. Schaffer and Mr. Pappajohn, directors of the Company,
guaranteed these extensions.  In consideration of their guarantees, in September
2004 the Company granted to Dr. Schaffer and Mr. Pappajohn  warrants to purchase
an  aggregate of 1,000,000  shares of the  Company's  common stock for $1.68 per
share. The Company valued these warrants at $1,416,500  using the  Black-Scholes
method. The value of these warrants was recorded as unearned debt issuance costs
and will be amortized  as  financing  costs over the 23 month period of the loan
guarantee.  During the three and nine  months  ended  September  30,  2004,  the
Company recorded a financing cost of $203,158 and $545,908, respectively.

                          COMPLIANCE WITH SECTION 16(a)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
the Company's  executive  officers and directors,  and persons who own more than
10% of a registered class of the Company's  equity  securities (who are referred
to as  "Reporting  Persons"),  to file  reports  of  ownership  and  changes  in
ownership  with the Securities and Exchange  Commission.  Reporting  Persons are
required by SEC regulations to furnish us with copies of all Section 16(a) forms
they file. Based on a review of the copies of reports  furnished to the Company,
the Company  believes  that during the year ended  December  31, 2003 all filing
requirements  applicable to its officers,  directors and ten percent  beneficial
owners were met.

                  STOCKHOLDER PROPOSALS FOR 2005 ANNUAL MEETING

     Stockholders who wish to present proposals appropriate for consideration at
the Company's  2005 Annual Meeting of  Stockholders  must submit the proposal in
proper  form to the  Company at its  address set forth on the first page of this
Proxy  Statement not later than April 1, 2005 in order for the proposition to be
considered  for  inclusion in the  Company's  proxy  statement and form of proxy
relating to such annual meeting.  Any such  proposals,  as well as any questions
related thereto, should be directed to the Assistant Secretary of the Company.

                                       20


                             ADDITIONAL INFORMATION

     The expenses in connection  with the  solicitation of proxies will be borne
by the  Company.  Solicitation  will be made by  mail,  but may  also be made by
telephone or personal  call by  officers,  directors or employees of the Company
who will not be specially  compensated  for such  solicitation.  The Company may
request that brokerage  houses and other nominees or fiduciaries  forward copies
of the Company's  Proxy  Statement,  Annual Report for period ended December 31,
2003 and Quarterly Report for period ended September 30, 2004 to Stockholders to
beneficial  owners of stock held in their names,  and the Company may  reimburse
them for reasonable out-of-pocket expenses incurred in doing so.

COPIES OF THE COMPANY'S ANNUAL REPORT ON FORM 10-KSB FOR THE YEAR ENDED DECEMBER
31, 2003 AND THE  COMPANY'S  QUARTERLY  REPORT ON FORM 10-QSB FOR THE  QUARTERLY
PERIOD ENDED SEPTEMBER 30, 2004 ARE BEING FURNISHED HEREWITH TO EACH STOCKHOLDER
OF RECORD AS OF THE CLOSE OF BUSINESS ON REDORD DATE.  ADDITIONAL  COPIES OF THE
COMPANY'S  ANNUAL  REPORT ON FORM 10-KSB AND THE COMPANY'S  QUARTERLY  REPORT ON
FORM 10-QSB WILL BE PROVIDED FOR A NOMINAL CHARGE UPON WRITTEN REQUEST TO:

                            PATIENT INFOSYSTEMS, INC.
                                46 Prince Street
                            Rochester, New York 14607
                        Attention: Yvonne Milligan-Prince


                                  OTHER MATTERS

     The Board of  Directors  does not  intend to bring any  matters  before the
Annual  Meeting other than as stated in this Proxy  Statement,  and is not aware
that any other  matters will be presented for action at the Annual  Meeting.  If
any other  matters  come before the Annual  Meeting,  the  persons  named in the
enclosed  form of proxy will vote the proxy with respect  thereto in  accordance
with their best judgment, pursuant to the discretionary authority granted by the
proxy.  Whether or not you plan to attend the Annual  Meeting in person,  please
complete, sign, date and return the enclosed proxy card promptly.

                                      By Order of the Board of Directors,

                                      /S/Roger L. Chaufournier

                                      Roger L. Chaufournier
                                      Chairman and Chief Executive Officer

                                       21


                                    EXHIBIT A


                            PATIENT INFOSYSTEMS, INC.
                  THIRD AMENDED AND RESTATED STOCK OPTION PLAN


     1. Purpose. The PATIENT INFOSYSTEMS,  INC. THIRD AMENDED AND RESTATED STOCK
OPTION  PLAN  (hereinafter  referred  to as the  "Plan") is  designed to furnish
additional  incentive to key  employees,  consultants  and  Directors of Patient
Infosystems,  Inc.,  a  Delaware  corporation  (hereinafter  referred  to as the
"Company"), and its parents or subsidiaries, upon whose judgment, initiative and
efforts the successful  conduct of the business of the Company largely  depends,
by encouraging such persons to acquire a proprietary  interest in the Company or
to increase the same,  and to  strengthen  the ability of the Company to attract
and retain in its employ,  or as a member of the Board of Directors,  persons of
training,  experience  and ability.  Such  purpose will be effected  through the
granting of "Incentive  Stock Options"  within the meaning of Section 422 of the
Internal  Revenue Code of 1986, as amended  (hereinafter the "Code") and options
which do not qualify as incentive stock options ("Non-Qualified Options").

     2. Administration.

          (a) The Plan shall be administered by a committee  chosen by the Board
     of  Directors  of  the  Company  (the  "Committee")  and  decisions  of the
     Committee  concerning the interpretation and construction of any provisions
     of the Plan or of any option  granted  pursuant to the Plan shall be final.
     In the absence of the Committee, the Plan will be administered by the Board
     of Directors of the Company.  The Company shall effect the grant of options
     under the Plan in  accordance  with the decisions of the  Committee,  which
     may, from time to time, adopt rules and regulations for the carrying out of
     the Plan. For purposes of the Plan, an option shall be deemed to be granted
     when a written  Option  Contract  is signed on behalf of the  Company  by a
     member of the Committee. Subject to the express provisions of the Plan, the
     Committee  shall  have  the  authority,   in  its  discretion  and  without
     limitation: to determine the individuals to receive options, the times when
     such individuals shall receive options,  the number of Shares to be subject
     to each option,  the term of each option,  the date(s) on which each option
     shall become exercisable,  whether an option is subject to vesting pursuant
     to Section 5(c) hereof, whether an option shall be exercisable in whole, in
     part,  or in  installments,  the  number of Shares  to be  subject  to each
     installment,  the date each installment shall become exercisable,  the term
     of each  installment,  the option  price of each  option,  and the terms of
     payment for Shares purchased by the exercise of each option;  to accelerate
     the  date  of  exercise  of  any   installment;   and  to  make  all  other
     determinations necessary or advisable for administering the Plan.

          (b) The Committee may grant Incentive Stock Options and  Non-Qualified
     Stock Options  pursuant to a single option agreement so long as each option
     is clearly  identified  as to its  status.  Notwithstanding  anything  else
     contained in the Plan,  if the Committee  issues a single option  agreement
     which  contains  both  Incentive  Stock  Options  and  Non-Qualified  Stock
     Options, the exercise of one cannot affect the exercise of the other.

                                       22


     3. Eligibility.  The persons who shall be eligible to receive options under
the Plan shall be Directors,  nominees to the Board of Directors,  employees and
consultants of the Company, or of any of its parents or subsidiaries;  provided,
however, Directors,  nominees to the Board of Directors and consultants, who are
not employees of the Company or any of its parents or subsidiaries, shall not be
eligible to receive  Incentive Stock Options.  Additionally,  no Incentive Stock
Option shall be granted to a person who would,  at the time of the grant of such
option,  own, or be deemed to own for purposes of Section 422(b)(6) of the Code,
more than 10% of the total  combined  voting  power of all  classes of shares of
stock of the  Company or its parents or  subsidiaries  unless at the time of the
grant of the Incentive Stock Option both of the following conditions are met:

          (a) The option  price is at least 110% of the fair market value of the
     shares of stock  subject  to the  Incentive  Stock  Option,  as  defined in
     Section 4(a) hereof, and

          (b) the option is, by its terms, not exercisable  after the expiration
     of five years from the date the Incentive Stock Option is granted.

     4. Shares Subject to Options.

          (a) Subject to the  provisions of Section 5(g) hereof,  options may be
     granted under the Plan to purchase in the aggregate not more than 3,500,000
     shares  of the $.01 par  value  Common  Stock of the  Company  (hereinafter
     referred  to as  "Shares"),  which  Shares may,  in the  discretion  of the
     Committee,  consist  either in whole or in part of authorized  but unissued
     Shares or Shares held in the treasury of the Company. Any Shares subject to
     an option which for any reason  expires or is terminated  unexercised as to
     such Shares shall continue to be available for options under the Plan.

          (b) To the extent the aggregate  fair market  value,  determined as of
     the time the option is  granted,  of Shares  for which  stock  options  are
     exercisable  for the first time by such  individual  in any calendar  year,
     under all incentive stock option plans of the Company or in any corporation
     which is a parent or  subsidiary  of the Company,  exceeds  $100,000,  such
     options shall be treated as Non-Qualified  Options.  However,  the value of
     the  Shares  for which  Incentive  Stock  Options  may be  granted  to such
     individual from the Company in a given year may exceed $100,000.

     5.  Terms and  Conditions  of  Options.  Options  shall be  granted  by the
Committee  pursuant to the Plan and shall be subject to the following  terms and
conditions:

          (a) Price. Each option shall state the number of Shares subject to the
     option and the  option  price,  which,  in the case of an  Incentive  Stock
     Option,  shall be not less than the fair  market  value of the Shares  with
     respect to which the option is granted at the time of the  granting  of the
     option. In addition, the option price shall be at least 110% of fair market
     value in the case of a grant of an  Incentive  Stock Option to a person who
     would at the time of the grant,  own,  or be deemed to own for  purposes of
     Section  422(b)(6) of the Code,  more than 10% of the total combined voting
     power  of  all  classes  of  Shares  of  the  Company  or  its  parents  or
     subsidiaries.  For purposes of this  subsection,  "fair market value" shall
     mean:

               (i) the mean  between  the bid and asked  price for the Shares on
          the business day  immediately  preceding  the date of the grant of the
          option;

                                       23


               (ii) the most  recent sale price for the Shares as of the date of
          the grant of the option; or

               (iii) such price as shall be determined by the Board of Directors
          of  the  Company  in an  attempt  made  in  good  faith  to  meet  the
          requirements of Section 422(b)(4) of the Code.

          (b)  Term.  The  term  of  each  option  shall  be  determined  by the
     Committee,  but in no event shall an option be exercisable  either in whole
     or in part after the  expiration  of ten years from the date on which it is
     granted.  Notwithstanding the foregoing, the Committee and an optionee may,
     by mutual  agreement,  terminate any option  granted to such optionee under
     the Plan. In the event of merger, consolidation, dissolution or liquidation
     which  results in a change of  control as defined in Section  368(c) of the
     Code (using the attribution rules of Section 318), all unexercised  options
     will  become  immediately  exercisable  for  a  period  of  one  year,  the
     effectiveness of such expiration shall be conditioned upon the consummation
     of any such transaction.

          (c) Vesting.  The Committee shall determine the vesting  schedule,  if
     any, for each issuance of options hereunder on a case-by-case basis, in its
     sole discretion.

          (d)  Non-Assignment  During Life. During the lifetime of the optionee,
     the option shall be exercisable  only by him and shall not be assignable or
     transferable  by  him,  whether  voluntarily  or by  operation  of  law  or
     otherwise, and no other person shall acquire any rights therein.

          (e) Death of Optionee.  In the event that an optionee  shall die prior
     to the  complete  exercise of options  granted to him under the Plan,  such
     remaining  options may be  exercised  in whole or in part after the date of
     the optionee's death only: (i) by the optionee's  estate or by or on behalf
     of such person or persons to whom the  optionee's  rights  under the option
     pass under the  optionee's  Will or the laws of descent  and  distribution;
     (ii) to the extent that the optionee was entitled to exercise the option at
     the date of his death; and (iii) prior to the expiration of the term of the
     option.

          (f)  Termination  of  Employment.  An Incentive  Stock Option shall be
     exercisable  during the lifetime of the optionee to whom it is granted only
     if, at all times during the period beginning on the date of the granting of
     the  option  and  ending on the day three  months  before  the date of such
     exercise,  he is an  employee  of the  Company  or any  of its  parents  or
     subsidiaries,  or an employee of a corporation or a parent or subsidiary of
     such  corporation  issuing or assuming  an option  granted  hereunder  in a
     transaction to which Section 424(a) of the Code applies; provided, however,
     that in the case of an  optionee  who is  disabled  within  the  meaning of
     Section  22(e)(3) of the Code,  the three month period  after  cessation of
     employment  during  which an Incentive  Stock  Option shall be  exercisable
     shall be one  year.  Notwithstanding  the  foregoing,  no  option  shall be
     exercisable after the expiration of its term thereof.  For purposes of this
     subsection, an employment relationship will be treated as continuing intact
     while the optionee is on military duty, sick leave or other bona fide leave
     of absence,  such as temporary employment by the Government,  if the period
     of such leave does not exceed 90 days, or, if longer,  so long as a statute
     or contract  guarantees  the  optionee's  right to  re-employment  with the
     Company,  or any of its  parents or  subsidiaries,  or another  corporation
     issuing or assuming an option  granted  hereunder in a transaction to which
     Section  424(a) of the Code  applies.  When the period of leave  exceeds 90
     days and the individual's  right to re-employment is not guaranteed  either
     by statute or by contract,  the employment  relationship  will be deemed to
     have terminated on the 91st day of such leave.

                                       24


          (g) Anti-Dilution Provisions. Subject to the provisions of Section 422
     of the Code  and the  regulations  promulgated  thereunder,  the  aggregate
     number and kind of Shares  available  for options  under the Plan,  and the
     number  and kind of Shares  subject  to,  and the  option  price  of,  each
     outstanding option shall be  proportionately  adjusted by the Committee for
     any  increase,  decrease or change in the total  outstanding  Shares of the
     Company  resulting  from  a  stock  dividend,   recapitalization,   merger,
     consolidation,  combination, exchange of Shares or similar transaction (but
     not by reason of the  issuance  or  purchase  of Shares by the  Company  in
     consideration for money, services or property).

          (h) Power to Establish Other Provisions.  Subject to the provisions of
     Section 422 of the Code and the regulations promulgated thereunder, options
     granted under the Plan shall contain such other terms and conditions as the
     Committee shall deem advisable.

     6. Exercise of Option. Options shall be exercised as follows:

          (a) Notice and Payment. Each option, or any installment thereof, shall
     be exercised,  whether in whole or in part, by giving written notice to the
     Company at its principal office,  specifying the number of Shares purchased
     and the purchase price being paid, and accompanied by the payment of all or
     such part of the purchase  price as shall be  specified  in the option,  by
     cash or by certified or bank check payable to the order of the Company.  If
     a registration  statement  covering the issuance of the Shares has not been
     filed under the Securities Act of 1933, as amended (hereinafter referred to
     as the "Act"),  and at the time of exercise is not effective and current in
     accordance  with the  requirements  of the Act, then each such notice shall
     also  contain  appropriate   representations  on  behalf  of  the  optionee
     regarding,   among  other  things,   compliance  with  the  Act,  available
     exemptions  from  registration,  investment  intent and  restrictions  upon
     resale of the Shares, as are deemed appropriate by the Company.

     Appropriate legends may be placed on any certificate for Shares received by
     an optionee  pursuant to the  exercise of an option in order to give notice
     of the transfer  restrictions  set forth herein,  and the Company may cause
     stop transfer orders to be placed against such certificates.  It shall be a
     further  condition to any exercise of the option and the purchase of Shares
     pursuant thereto that the Company counsel be satisfied that the issuance of
     such  shares  will  be in  compliance  with  the Act  and  any  other  laws
     applicable thereto, and the Company shall be entitled to receive such other
     information,  assurances, documents, representations or warranties as it or
     its counsel may reasonably require with respect to such compliance.

          (b) Issuance of  Certificates.  Certificates  representing  the Shares
     purchased by the optionee shall be issued as soon as practicable  after the
     optionee has complied with the provisions of Section 6(a) hereof.

          (c) Rights as a  Shareholder.  The optionee  shall have no rights as a
     Shareholder  with  respect  to the Shares  purchased  until the date of the
     issuance to him of a Certificate representing such Shares.

                                       25


          (d)  Disposition of Shares.  Subject to the provisions of Section 6(a)
     hereof, any disposition,  within the meaning of Section 424(c) of the Code,
     of Shares  acquired by the exercise of an Incentive Stock Option within two
     years  from the date of grant of the  option or within  one year  after the
     transfer of the Shares to the optionee shall be a disqualifying disposition
     as defined  in  Section  421(b) of the Code;  provided,  however,  that the
     foregoing  holding  periods  shall not apply to the  disposition  of Shares
     after the death of the  optionee  by the  estate of the  optionee,  or by a
     person who  acquired the Shares by bequest or  inheritance  or by reason of
     the death of the optionee.  For purposes of the preceding sentence,  in the
     case of a  transfer  of  Shares  by an  insolvent  optionee  to a  trustee,
     receiver  or similar  fiduciary  in any  proceeding  under  Title 11 of the
     United  States  Code or any  similar  insolvency  proceeding,  neither  the
     transfer,  nor any other  transfer  of such  Shares for the  benefit of his
     creditors in such proceeding, shall constitute a disposition.

          (e) Order of Option  Exercise.  An optionee  may  exercise the options
     granted by the  Company  under the Plan in any order the  optionee  chooses
     regardless of the chronological  order in which the options were granted by
     the Company.

     7. Special  Provisions  Regarding Option Grants to Non-Employee  Directors.
Pursuant to the terms of this Plan,  each  non-employee  nominee to the Board of
Directors of this  Corporation,  at the sole  discretion of the  Committee,  may
receive a one-time grant of a Non-Qualified  Option,  effective upon the date of
his/her  nomination  to the Board of Directors of the  Corporation,  to purchase
50,000 Shares. In the event such one-time grant of a Non-Qualified Option is not
granted to a  non-employee  nominee to the Board of  Directors  upon the date of
his/her  nomination  to the Board of  Directors,  such  Non-Qualified  Option to
purchase  50,000  Shares  shall  automatically  be granted upon the date of such
nominee's  election as a  non-employee  Director to the Board of Directors.  The
exercise  price  for  such  option  shall  equal  the fair  market  value of the
Corporation's  Common Stock on the grant date. Each such option shall vest as to
exercisability  with respect to the first 20% of the shares  subject  thereto on
the  first  anniversary  date of the  grant  date of such  option,  and as to an
additional  20% of the  shares  subject  thereto on each of the  second,  third,
fourth and fifth  anniversary  dates of the grant date. Any such options granted
to non-employee  Directors or no-employee  nominees to the Board of Directors of
the Corporation shall be exercisable only during the holder's term as a Director
of the Corporation, and shall automatically expire upon the date that a Director
is no longer  serving as a Director,  except  that an option may be  exercisable
after  the  death,  disability,  as  defined  in  Section  22(e)(3)  of the Code
("Disability"),  or  retirement  from the  Board at the age of 65 or  thereafter
("Retirement"),  of a holder  while a Director  of the Company at any time until
the  earlier  to  occur of (i) the one year  anniversary  of the date of  death,
Disability, or Retirement and (ii) the expiration of the term of such option. No
shares of Common  Stock  issuable  upon the  exercise  of an option may be sold,
assigned,  pledged or otherwise transferred for a period of six months after the
later to occur of (x) the adoption of the Plan by the Company's shareholders and
(y) the grant of the option,  as is  specified in Rule 16b-3 (or other period of
time  specified  in such rule as such rule may be amended  from time to time) of
the  Securities  Exchange Act of 1934, as amended (the  "Exchange  Act").  It is
intended  that  this  part  of the  Plan  as it  applies  to  option  grants  to
non-employee  Directors  will  constitute a "formula plan" within the meaning of
Rule 16b-3 under the  Exchange  Act, and the  provisions  of the Plan and of any
option  agreement  made  pursuant  to the Plan will be  interpreted  and applied
accordingly. At any time the Committee may suspend or terminate this part of the
Plan and make  such  additions  or  amendments  thereto  as it deems  advisable;
provided,  that such  additions or amendments  are made in compliance  with Rule
16b-3 of the Exchange  Act (as such rule may be amended from time to time);  and
provided,  further,  that the terms of this paragraph  shall not be amended more
than once every six months  (other than to comply  with the  federal  securities
laws, the Code, or ERISA).

                                       26


     8. Term of Plan.  Options may be granted  pursuant to the Plan from time to
time  within a period of ten years  after  the date the Plan is  adopted  by the
Board of  Directors  of the  Company  or the date  the Plan is  approved  by the
holders of a majority of the outstanding  Shares of the Company,  whichever date
is  earlier.  However,  the Plan shall not take  effect  until  approved  by the
holders  of a  majority  of the  outstanding  Shares of the  Company,  at a duly
constituted meeting thereof,  held within 12 months before or after the date the
Plan is adopted by the Board of Directors.

     9.  Amendment and  Termination  of Plan.  The  Committee,  without  further
approval  of the  Shareholders  of the  Company,  may at  any  time  suspend  or
terminate the Plan,  or may amend it from time to time in any manner;  provided,
however,  that no amendment  shall be effective  without  prior  approval of the
Shareholders of the Company which would:  (i) except as provided in Section 5(g)
hereof,  increase the maximum  number of Shares for which options may be granted
under the  Plan;  (ii)  change  the  eligibility  requirements  for  individuals
entitled  to receive  options  under the Plan;  or (iii) cause  Incentive  Stock
Options  granted or to be granted under the Plan to fail to qualify as Incentive
Stock  Options  under  Section 422 of the Code and the  regulations  promulgated
thereunder.

     10.  Shares  Reserved.  The Board of Directors of the Company  shall at all
times  during the term of this Plan  reserve and keep  available  such number of
Shares as will be sufficient to satisfy the requirements of this Plan, and shall
pay all original issue taxes on the exercise of options,  and all other fees and
expenses necessarily incurred by the Company in connection therewith.

     11.  Application  of  Proceeds.  The  proceeds of the sale of Shares by the
Company under the Plan will  constitute  general funds of the Company and may be
used by the Company for any purpose.

Date approved by

Board of Directors - _______________

Shareholders - _____________________

                                       27


                                    EXHIBIT B

                            PATIENT INFOSYSTEMS, INC.
                             AUDIT COMMITTEE CHARTER

Organization

This charter governs the operations of the audit committee.  The committee shall
review and reassess the charter at least annually and obtain the approval of the
board of directors.  The committee shall be appointed by the board of directors,
each of whom are  independent  of  management  and the  Company.  Members of the
committee shall be considered  independent if they have no relationship that may
interfere  with the  exercise  of their  independence  from  management  and the
Company.  All committee members shall be financially  literate,  or shall become
financially literate within a reasonable period of time after appointment to the
committee,  and at least one member shall have  accounting or related  financial
management expertise.

Statement of Policy

The audit  committee  shall  provide  assistance  to the board of  directors  in
fulfilling  their  oversight  responsibility  to  the  shareholders,   potential
shareholders,  the investment  community,  and others  relating to the Company's
financial  statements  and the  financial  reporting  process,  the  systems  of
internal  accounting and financial  controls,  the internal audit function,  the
annual independent audit of the Company's  financial  statements,  and the legal
compliance and ethics programs as established by management and the board. In so
doing,  it is the  responsibility  of the  committee  to maintain  free and open
communication between the committee, independent auditors, the internal auditors
and management of the Company.  In discharging its oversight role, the committee
is empowered to investigate any matter brought to its attention with full access
to all books, records,  facilities and personnel of the Company and the power to
retain outside counsel or other experts for this purpose.

Responsibilities and Processes

The primary  responsibility  of the audit  committee is to oversee the Company's
financial  reporting process on behalf of the board and to report the results of
their  activities  to the board.  Management  is  responsible  for preparing the
Company's financial statements, and the independent auditors are responsible for
auditing  those  financial  statements.  The  committee,  in  carrying  out  its
responsibilities,  believes its policies and procedures  should remain flexible,
in order to best react to changing  conditions and circumstances.  The committee
should  take the  appropriate  actions to set the overall  corporate  "tone" for
quality  financial  reporting,   sound  business  risk  practices,  and  ethical
behavior.

The following shall be the principal  recurring processes of the audit committee
in carrying out its oversight responsibilities. The processes are set forth as a
guide  with  the  understanding  that  the  committee  may  supplement  them  as
appropriate.

o    The committee  shall have a clear  understanding  with  management  and the
     independent   auditors  that  the   independent   auditors  are  ultimately
     accountable to the board and the audit committee, as representatives of the
     Company's shareholders. The committee shall have the ultimate authority and
     responsibility to evaluate and, where appropriate,  replace the independent
     auditors.  The committee shall discuss with the auditors their independence
     from  management  and the Company  and the matters  included in the written
     disclosures  required by the Independence  Standards Board.  Annually,  the
     committee  shall  review and  recommend  to the board the  selection of the
     Company's independent auditors, subject to shareholders' approval.

o    The committee shall discuss with the internal  auditors and the independent
     auditors the overall scope and plans for their respective audits, including
     the  adequacy of staffing  and  compensation.  Also,  the  committee  shall
     discuss  with  management,  the  internal  auditors,  and  the  independent
     auditors the adequacy and  effectiveness  of the  accounting  and financial
     controls,  including the Company's  system to monitor and manage risk,  and
     legal and ethical compliance  programs.  Further,  the committee shall meet
     separately with the internal auditors and the independent auditors with and
     without management present, to discuss the results of their examinations.

                                       28


o    The committee shall review the interim financial statements with management
     and the independent auditors prior to the filing of the Company's Quarterly
     Report on Form 10-Q.  Also, the committee  shall discuss the results of the
     quarterly  review and any other matters  required to be communicated to the
     committee by the  independent  auditors under generally  accepted  auditing
     standards.  The chair of the committee  may represent the entire  committee
     for the purpose of this review.

o    The committee shall review with management and the independent auditors the
     financial  statements to be included in the Company's Annual Report on Form
     10-K (or the annual  report to  shareholders  if  distributed  prior to the
     filing of Form 10-K),  including their judgment about the quality, not just
     acceptability,  of accounting principles, the reasonableness of significant
     judgments,  and the clarity of the disclosures in the financial statements.
     Also,  the committee  shall discuss the results of the annual audit and any
     other  matters  required  to  be  communicated  to  the  committee  by  the
     independent auditors under generally accepted auditing standards.





                                       29


                               EXHIBIT PROXY CARD

                                      PROXY
                            PATIENT INFOSYSTEMS, INC.
              THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS FOR
                       THE ANNUAL MEETING OF STOCKHOLDERS
                         TO BE HELD ON DECEMBER 23, 2004

     The undersigned hereby appoints Kent Tapper and/or Roger Chaufournier, each
with full power of substitution, as proxies for the undersigned to attend the
Annual Meeting of Stockholders of Patient Infosystems, Inc. (the "Company"), to
be held at 46 Prince St., Rochester, New York 14607 on December 23, 2004 at 10
a.m., Eastern Time, or any adjournment thereof, and to vote the number of shares
of capital stock of the Company that the undersigned would be entitled to vote,
and with all the power the undersigned would possess, if personally present, as
follows:

1. To elect the following nominees for election as directors:

                  Edward B. Berger
                  Robert M. Kaufman
                  Donald R. Ryan
                  Derace L. Schaffer, M.D.
                  Roger L. Chaufournier
                  John Pappajohn

     [_]  FOR ALL NOMINEES

     [_]  WITHHOLD AUTHORITY

     (To withhold authority to vote for an individual nominee, write the
     nominee's name on the line provided below)

               --------------------------------


2.   Approval of an amendment to the Company's Second Amended and Restated Stock
     Option Plan (a) to expand the class of eligible participants of such plan
     to include nominees to the Board of Directors and consultants, and (b) to
     increase from 36,000 to 50,000 the number of shares of common stock
     underlying the one-time grant of a Non-Qualified Stock Option to which
     non-employee directors or non-employee nominees to the Board of Directors
     may be entitled.

              [_] FOR [_] AGAINST [_] ABSTAIN

3.   Ratification of the appointment of McGladrey & Pullen LLP as the Company's
     independent auditors for the fiscal year ending December 31, 2004.

              [_] FOR [_] AGAINST [_] ABSTAIN


The Proxies will vote as specified herein or, if a choice is not specified, they
will vote "FOR" the proposals set forth above. In their discretion, the Proxies
are authorized to vote upon such other business as may properly come before the
meeting or any adjournment thereof.

     When shares are held by two or more persons as joint tenants, both or all
should sign. When signing as attorney, executor, administrator, trustee or
guardian, please give full title as such. If a corporation, please sign in full
corporate name by president or other authorized officer. If a partnership,
please sign in partnership name by authorized person.

Signature:__________________ Signature:__________________ DATE: ________________