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Therapy for Chemo - Pretreated Metastatic Urothelial Cancer ( mUC ) with the Antibody - Drug Conjugate (ADC), Sacituzumab Govitecan (IMMU - 132) Scott T. Tagawa 1 , Allyson J. Ocean 1 , Elaine Lam 2 , Philip Saylor 3 , Aditya Bardia 3 , Julio J. Hajdenberg 4 , Alicia K. Morgans 5 , Kevin Kalinsky 6 , Matthew D. Galsky 7 , Bishoy Faltas 1 , Ana Molina 1 , Emerson Lim 6 , Pius Maliakal 8 , Robert M. Sharkey 8 , Boyd Mudenda 8 , William A. Wegener 8 , David M. Goldenberg 8 1 Weill Cornell Medicine, New York, NY; 2 University of Colorado Cancer Center, Aurora, CO; 3 Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA; 4 UF Health Cancer Center - Orlando Health, Orlando, FL ; 5 Vanderbilt Ingram Cancer Center, Nashville, TN; 6 Columbia University - Herbert Irving Comprehensive Cancer Center, New York, NY; 7 Icahn School of Medicine Mount Sinai, Tisch Cancer Institute, New York, NY; 8 Immunomedics, Inc., Morris Plains, NJ Sacituzumab govitecan (IMMU - 132) is an investigational agent. Drs. Wegener, Sharkey, Maliakal, Mudenda and Goldenberg are employees of Immunomedics which provided funding for the other investigators for the conduct of this trial . Abstract #: 327 • 44 patients received 556 doses (278 cycles) of IMMU - 132 • Median number of doses: 6 (range, 1 - 50) • 36 Response - Assessable patients (75% ≥ 2 lines of prior therapy ) • Best response: 1 CR, 10 PRs, 19 SDs, 6 PDs • Objective Response Rate: 31% (11/36) (95% CI: 17%, 48%) – 1 prior chemotherapy: 44% (4/9) – 2 to 6 prior chemotherapies: 26% (7/27) – Prior I - O: 17% (2/12) • Median duration of response: 7.5 months (95% CI: 4.4, 12.9 ) • Clinical benefit rates: PR + SD ≥ 4 mos , 63% ; PR + SD ≥6 mos , 52% • Median PFS: 7.2 months (95% CI, 6.7, 11.7) • Median OS: 15.5 months (95% CI, 8.9, 17.2) • Major grade ≥ 3 toxicity: neutropenia (29.6%), febrile neutropenia (11.1%) • No treatment - related SAEs or death; no immune reaction to ADC or antibody response SUMMARY CONCLUSION With an ORR of 31% and a median duration of response of 7.5 months in a heavily pre - treated population, sacituzumab govitecan (IMMU - 132) is an active and promising agent as a 2nd or later - line monotherapy for platinum - or I - O - pretreated, metastatic (stage IV) mUC patients