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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*


                           CIPHERGEN BIOSYSTEMS, INC.
          -------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.001 Par Value
          -------------------------------------------------------------
                         (Title of Class of Securities)

                                   17252Y 10 4
          -------------------------------------------------------------
                                 (CUSIP Number)


Check the following box if a fee is being paid with this statement [ ]. (A fee
is not required only if the filing person: (1) has a previous statement on the
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has no amendment subsequent thereto
reporting beneficial ownership of five percent or less of such class.) (See Rule
13d-7.)

*The remainder of this cover page shall be filled our for a reporting person's
initial filing of this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


                        (Continued on following page(s))
                                Page 1 of 5 Pages


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CUSIP NO. 17252Y 10 4                   13G                   PAGE 2 OF 5 PAGES


1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         S.R. One, Limited
         23-1729901

2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                   (a)  [  ]
                                                                   (b)  [  ]
3        SEC USE ONLY


4        CITIZENSHIP OR PLACE OF ORGANIZATION
         Pennsylvania Business Trust

                                            5     SOLE VOTING POWER
 NUMBER OF                                        1,952,987
  SHARES
BENEFICIALLY                                6     SHARED VOTING POWER
 OWNED BY
   EACH
 REPORTING                                  7     SOLE DISPOSITIVE POWER
  PERSON                                          1,952,987
   WITH
                                            8     SHARED DISPOSITIVE POWER


9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,952,987

10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         [ ]

11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
         7.3%

12       TYPE OF REPORTING PERSON*
         CO


                      *SEE INSTRUCTION BEFORE FILLING OUT!
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CUSIP NO. 17252Y 10 4                  13G                    PAGE 3 OF 5 PAGES


Item 1.      (a).           Name of Issuer:

                            Ciphergen Biosystems, Inc.

             (b).           Address of Issuer's Principal Executive Offices:

                            490 San Antonio Road
                            Palo Alto, CA  94306

Item 2.      (a).           Name of Person Filing:

                            S.R. One, Limited

             (b).           Address of Principal Business office:

                            Four Tower Bridge
                            200 Barr Harbor Drive, Suite 250
                            West Conshohocken, PA  19428-2977

             (c).           Citizenship:

                            Pennsylvania

             (d).           Title of Class of Securities:

                            Common stock.

             (e).           CUSIP Number:

                            17252Y 10 4

Item 3.                     Not Applicable.

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CUSIP NO. 17252Y 10 4                  13G                    PAGE 4 OF 5 PAGES


Item 4.                     Ownership.

                            The information in items 1 and 5 through 11
                            on the cover pages (page 2) on Schedule 13G
                            is hereby incorporated by reference. Shares
                            reported include 34,400 issued and
                            exercisable stock options granted by Issuer.

Item 5.                     Ownership of Five Percent or Less of a Class:

                            If this statement is being filed to report
                            the fact that as of the date hereof the
                            reporting person has ceased to be the
                            beneficial owner of more than five percent
                            of the class of securities, check the
                            following [ ].

Item 6.                     Ownership of More Than Five Percent on Behalf
                            of Another Person:

                            Not applicable.

Item 7.                     Identification and Classification of Subsidiaries
                            Which Acquired the Security Being Reported on by
                            the Parent Holding Company:

                            Not applicable.

Item 8.                     Identification and Classification of Members of
                            the Group:

                            Not applicable.



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CUSIP NO.                              13G                    PAGE 5 OF 5 PAGES


Item 9.                     Notice of Dissolution of Group:

                            Not Applicable

Item 10.                    Certification:

                            By signing below I certify that, to the best of
                            my knowledge and belief, the securities referred
                            to above were acquired and are not held for the
                            purpose of or with the effect of changing or
                            influencing the control of the issuer of such
                            securities and were not acquired in connection
                            with or as a participant in any transaction having
                            such purpose or effect.

                            Signature:

                            After reasonable inquiry and to the best of my
                            knowledge and belief, I certify that the information
                            set forth in this statement is true, complete and
                            correct.


                                         S.R. One, Limited

                                         By:     /s/
                                             ----------------------------------
                                                 Donald A. Parman
                                                 Secretary


Dated:  February 13, 2001