Schedule 13G                                                        Page 1 of 5



=================== ============================================================
SEC 1745            POTENTIAL PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF
(6-00)              INFORMATION CONTAINED IN THIS FORM ARE NOT REQUIRED TO
                    RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB
                    CONTROL NUMBER.
=================== ============================================================
                                                      -------------------------
                            UNITED STATES                 OMB APPROVAL
                  SECURITIES AND EXCHANGE COMMISSION  -------------------------
                        WASHINGTON, D.C. 20549        OMB Number:     3235-0145
                                                      -------------------------
                             SCHEDULE 13G             Expires: October 31, 2002
                                                      -------------------------
                                                      Estimated average burden
                                                      hours per response...14.9
                                                      -------------------------




                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                             (AMENDMENT NO._______)*


                           Ciphergen Biosystems, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   17252Y 10 4
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                               September 28, 2000
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

/ /      Rule 13d-1(b)

/ /      Rule 13d-1(c)

/X/      Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


Schedule 13G                                                         Page 2 of 5


CUSIP No.   17252Y 10 4
--------------------------------------------------------------------------------

         1.   Names of Reporting Persons.  I.R.S. Identification Nos. of above
              persons (entities only).

              William E. Rich

--------------------------------------------------------------------------------

         2.   Check the Appropriate Box if a Member of a Group
              (See Instructions)

              (a) / /

              (b) / /
--------------------------------------------------------------------------------

         3.   SEC Use Only

--------------------------------------------------------------------------------

         4.   Citizenship or Place of Organization  United States of America

--------------------------------------------------------------------------------
Number of Shares
Beneficially
Owned by Each
Reporting Person   5.    Sole Voting Power 1,386,690
With
                   -------------------------------------------------------------

                   6.    Shared Voting Power  0

                   -------------------------------------------------------------

                   7.    Sole Dispositive Power  0

                   -------------------------------------------------------------

                   8.    Shared Dispositive Power  1,417,218

--------------------------------------------------------------------------------
         9.   Aggregate Amount Beneficially Owned by Each Reporting Person

              1,417,218
--------------------------------------------------------------------------------

         10.  Check if the Aggregate Amount in Row (9) Excludes Certain Shares
              (See Instructions)

--------------------------------------------------------------------------------

         11.  Percent of Class Represented by Amount in Row (9)  5.3%

--------------------------------------------------------------------------------
         12.  Type of Reporting Person (See Instructions)

              William E. Rich - IN






--------------------------------------------------------------------------------




Schedule 13G                                                         Page 3 of 5


ITEM 1.

          (a)       Ciphergen Biosystems, Inc.

          (b)       6611 Dumbarton Circle, Fremont, CA 94555

ITEM 2.

          (a)       William E. Rich

          (b)       Ciphergen Biosystems, Inc., 6611 Dumbarton Circle, Fremont,
                    CA 94555

          (c)       United States of America

          (d)       Common Stock

          (e)       17252Y 10 4

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SECTIONS 240.13d-1(b) OR
        240.13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

         Not Applicable.

ITEM 4.  OWNERSHIP

          (a)       Amount beneficially owned: 1,417,218 shares

          (b)       Percent of class: 5.3%

          (c)       Number of shares as to which the person has:

                    (i)       Sole power to vote or to direct the vote:
                              1,386,690 shares

                    (ii)      Shared power to vote or to direct the vote: 0

                    (iii)     Sole power to dispose or to direct the disposition
                              of: 0 shares

                    (iv)      Shared power to dispose or to direct the
                              disposition of: 1,417,218 shares

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

         Not Applicable.

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

         Not Applicable.




Schedule 13G                                                         Page 4 of 5



ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
         SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

         Not Applicable.

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

         Not Applicable.

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

         Not Applicable.

ITEM 10. CERTIFICATION

         Not Applicable.




Schedule 13G                                                         Page 5 of 5


                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.



                                               February 7, 2001
                                   -------------------------------------------
                                                      Date


                                             /s/ William E. Rich
                                   -------------------------------------------
                                                   Signature


                                                William E. Rich
                                   -------------------------------------------
                                                    Print